Project Vasculitis | GSK       Research       |          Userflow         |          Wireframe         |         Prototype        |          Interaction Design

Mapped out the buyer decision journey and roadmapped features based on it. 

Sitemap design: It's important to test the sitemap with different users and gather feedback, this will allow to make necessary adjustments to improve the user experience.
A touchscreen information board is a digital display that allows users to interact with the displayed content using their fingers.
Prototype design for an interactive screen display should balance user needs, technology constraints, scalability.

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My role: UX Interaction Designer

Vasculitis | GSK

ANCA-associated vasculitis causes vessel damage, mainly affecting small vessels without many immune deposits. It's linked to specific ANCA (autoantibodies) targeting neutrophils, vital for fighting infections by releasing substances against pathogens. ANCA in AAV binds to PR3 or MPO proteins in neutrophils, contributing to vessel damage.

Tests for ANCA involve IIF and ELISA methods. IIF identifies ANCA via staining patterns (cANCA or pANCA), while ELISA measures the protein ANCA binds to. However, some AAV patients may lack detectable ANCA. It's uncertain whether these ANCA-negative cases have undetectable ANCA, different ANCA specificity, or an AAV mechanism not involving ANCA.

To develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA).

– Overview: infographic of content to be available for download here and/or at the end of the clinical case
– Photo/no-photo? Patient description
– Patient 1: Slide 1: patient overview – Why brought into ER Slide 2: Work-up
– Write description of how to use the classification tool Show calculator (EULAR guidelines) Place for user to enter patient’s score
– You were right! Description of Why
– You were wrong – explanation of the correct answer
– Special notifications: Based on decision tree
– Guideline infographic

The EGPA development set included 107 EGPA cases and 450 comparators. The validation set added 119 EGPA cases and 437 comparators. Regression analysis from 91 items identified 11 for EGPA, of which 7 were kept.

The final criteria and weights were: eosinophil count ≥1 109/liter (+5), obstructive airway disease (+3), nasal polyps (+3), cytoplasmic ANCA or anti–proteinase 3 ANCA positivity (+3), eosinophilic inflammation (+2), mononeuritis multiplex/motor neuropathy (+1), and hematuria (+1). EGPA diagnosis required a cumulative score of ≥6 points after excluding vasculitis mimics. In the validation set, these criteria showed 85% sensitivity (95% CI 77–91%) and 99% specificity (95% CI 98–100%).

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